The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity
JL Gommerman, JL Browning, CF Ware - Cytokine & growth factor reviews, 2014 - Elsevier
The Lymphotoxin (LT) pathway is best known for its role in orchestrating the development
and homeostasis of lymph nodes and Peyer's patches through the regulation of homeostatic
chemokines. More recently an appreciation of the LTβR pathway in the production of Type I
interferons (IFN-I) during homeostasis and infection has emerged. LTβR signaling is
essential in differentiating stromal cells and macrophages in lymphoid organs to rapidly
produce IFN-I in response to virus infections independently of the conventional TLR …
and homeostasis of lymph nodes and Peyer's patches through the regulation of homeostatic
chemokines. More recently an appreciation of the LTβR pathway in the production of Type I
interferons (IFN-I) during homeostasis and infection has emerged. LTβR signaling is
essential in differentiating stromal cells and macrophages in lymphoid organs to rapidly
produce IFN-I in response to virus infections independently of the conventional TLR …
