[HTML][HTML] Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice
PJ Blackshear, DJ Stumpo, E Carballo… - Journal of Biological …, 1997 - ASBMB
PHAS-I is the prototype of a group of eIF4E-binding proteins that can regulate mRNA
translation in response to hormones and growth factors. To investigate the importance of
PHAS-I in the physiology of the intact animal, we disrupted the PHAS-I gene in mice. Tissues
and cells derived from the knockout mice contained no detectable PHAS-I protein. A related
protein, PHAS-II, and eIF4E were readily detectable in tissues from these animals, but
neither appeared to be changed in a compensatory manner. Mice lacking PHAS-I appeared …
translation in response to hormones and growth factors. To investigate the importance of
PHAS-I in the physiology of the intact animal, we disrupted the PHAS-I gene in mice. Tissues
and cells derived from the knockout mice contained no detectable PHAS-I protein. A related
protein, PHAS-II, and eIF4E were readily detectable in tissues from these animals, but
neither appeared to be changed in a compensatory manner. Mice lacking PHAS-I appeared …