Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis
VE Gould, A Orucevic, H Zentgraf, P Gattuso… - Human pathology, 2002 - Elsevier
Nuclear pore complexes (NPCs) are elaborate macromolecular structures that regulate the
bidirectional nucleocytoplasmic traffic system. In vertebrate cells, NPCs include a family of
50 to 100 proteins termed nucleoporins (Nups). The 88-kD Nup has been found to be linked
in a dynamic subcomplex with the oncogenic CAN/Nup214. Applying a polyclonal antiserum
to Nup88 on paraffin sections, we found that it immunoreacts with numerous malignant
neoplasms. All carcinomas reacted irrespective of site, type, or degree of differentiation; …
bidirectional nucleocytoplasmic traffic system. In vertebrate cells, NPCs include a family of
50 to 100 proteins termed nucleoporins (Nups). The 88-kD Nup has been found to be linked
in a dynamic subcomplex with the oncogenic CAN/Nup214. Applying a polyclonal antiserum
to Nup88 on paraffin sections, we found that it immunoreacts with numerous malignant
neoplasms. All carcinomas reacted irrespective of site, type, or degree of differentiation; …