Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
JD Cooper, DJ Smyth, AM Smiles, V Plagnol… - Nature …, 2008 - nature.com
JD Cooper, DJ Smyth, AM Smiles, V Plagnol, NM Walker, JE Allen, K Downes, JC Barrett…
Nature genetics, 2008•nature.comWe carried out a meta-analysis of data from three genome-wide association (GWA) studies
of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of
European ancestry. We obtained further support for 4q27 (IL2-IL21, P= 1.9× 10− 8) and, after
genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing
evidence for four previously unknown and distinct risk loci in chromosome regions 6q15
(BACH2, P= 4.7× 10− 12), 10p15 (PRKCQ, P= 3.7× 10− 9), 15q24 (CTSH, P= 3.2× 10− 15) …
of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of
European ancestry. We obtained further support for 4q27 (IL2-IL21, P= 1.9× 10− 8) and, after
genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing
evidence for four previously unknown and distinct risk loci in chromosome regions 6q15
(BACH2, P= 4.7× 10− 12), 10p15 (PRKCQ, P= 3.7× 10− 9), 15q24 (CTSH, P= 3.2× 10− 15) …
Abstract
We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 × 10−8) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 × 10−12), 10p15 (PRKCQ, P = 3.7 × 10−9), 15q24 (CTSH, P = 3.2 × 10−15) and 22q13 (C1QTNF6, P = 2.0 × 10−8).
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