The proinflammatory cytokines tumor necrosis factor (TNF) α and interleukin (IL) 1β have
been strongly implicated in the pathogenesis of neuropathic pain, but the intracellular
signaling of these cytokines in glial cells is not fully understood. TNF receptor-associated
factor 6 (TRAF6) plays a key role in signal transduction in the TNF receptor superfamily and
the IL-1 receptor superfamily. In this study, we investigated the role of TRAF6 in neuropathic
pain in mice after spinal nerve ligation (SNL). SNL induced persistent TRAF6 upregulation in …