[HTML][HTML] Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure
R Wang, Q Li, CM Helfer, J Jiao, J You - Journal of Biological Chemistry, 2012 - ASBMB
Chromatin structure organization is crucial for regulating many fundamental cellular
processes. However, the molecular mechanism that regulates the assembly of higher-order
chromatin structure remains poorly understood. In this study, we demonstrate that Brd4
(bromodomain-containing protein 4) protein participates in the maintenance of the higher-
order chromatin structure. Brd4, a member of the BET family of proteins, has been shown to
play important roles in cellular growth control, cell cycle progression, and cancer …
processes. However, the molecular mechanism that regulates the assembly of higher-order
chromatin structure remains poorly understood. In this study, we demonstrate that Brd4
(bromodomain-containing protein 4) protein participates in the maintenance of the higher-
order chromatin structure. Brd4, a member of the BET family of proteins, has been shown to
play important roles in cellular growth control, cell cycle progression, and cancer …