[PDF][PDF] The metabolic milieu of metastases
WJ Sullivan, HR Christofk - Cell, 2015 - cell.com
Cell, 2015•cell.com
To colonize the liver, colon cancer metastases must overcome hypoxia and other metabolic
stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and
miR-551a expression, which derepresses creatine kinase expression and allows energy to
be captured from extracellular ATP through generation and import of phosphocreatine.
stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and
miR-551a expression, which derepresses creatine kinase expression and allows energy to
be captured from extracellular ATP through generation and import of phosphocreatine.
To colonize the liver, colon cancer metastases must overcome hypoxia and other metabolic stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and miR-551a expression, which derepresses creatine kinase expression and allows energy to be captured from extracellular ATP through generation and import of phosphocreatine.
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