Deficient autophagy results in mitochondrial dysfunction and FSGS

T Kawakami, IG Gomez, S Ren, K Hudkins… - Journal of the …, 2015 - journals.lww.com
FSGS is a heterogeneous fibrosing disease of the kidney, the cause of which remains poorly
understood. In most cases, there is no effective treatment to halt or retard progression to
renal failure. Increasing evidence points to mitochondrial dysfunction and the generation of
reactive oxygen species in the pathogenesis of CKD. Autophagy, a major intracellular
lysosomal degradation system, performs homeostatic functions linked to metabolism and
organelle turnover. We prevented normal autophagic pathways in nephrons of mice by …