The emerging science of epigenomics

PA Callinan, AP Feinberg - Human molecular genetics, 2006 - academic.oup.com
PA Callinan, AP Feinberg
Human molecular genetics, 2006academic.oup.com
One of the most exciting frontiers in both epigenetics and genome sciences is the new field
of epigenomics. This new discipline promises novel insights into the genome because of its
potential to detect quantitative alterations, multiplex modifications and regulatory sequences
outside of genes. A number of new epigenomic strategies are emerging to exploit microarray
formats with varying substrate choice, pre-processing and data analysis. These approaches
are designed to detect large numbers of variations in DNA methylation and chromatin …
Abstract
One of the most exciting frontiers in both epigenetics and genome sciences is the new field of epigenomics. This new discipline promises novel insights into the genome because of its potential to detect quantitative alterations, multiplex modifications and regulatory sequences outside of genes. A number of new epigenomic strategies are emerging to exploit microarray formats with varying substrate choice, pre-processing and data analysis. These approaches are designed to detect large numbers of variations in DNA methylation and chromatin modification. Many groups are joining forces toward developing an organized Human Epigenome Project to exploit these new technologies to better understand the basis of normal development and human disease.
Oxford University Press