Animals in experimental neoplasia

P Workman - Br J Cancer, 1998 - ncbi.nlm.nih.gov
Br J Cancer, 1998ncbi.nlm.nih.gov
While we recognize and encourage the development of alternative research techniques
which do not involve animals, we consider that there are many questions in oncology
research which can be answered only by the study of tumours growing in vivo. Animals with
local or disseminated tumours are likely to experience pain and/or distress, thus justifying
special care and attention from both licensees and others involved in their welfare.
Associated techniques including surgical preparation, irradiation, and drug administration …
While we recognize and encourage the development of alternative research techniques which do not involve animals, we consider that there are many questions in oncology research which can be answered only by the study of tumours growing in vivo. Animals with local or disseminated tumours are likely to experience pain and/or distress, thus justifying special care and attention from both licensees and others involved in their welfare. Associated techniques including surgical preparation, irradiation, and drug administration may increase the severity of an experimental procedure. Recognizing this, the United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) in 1988 set up an ad hoc committee to develop guidelines for research workers using animals in experimental neoplasia. The UKCCCR (for membership see below*) is charged by the major bodies involved in the funding of cancer research in the UK with the co-ordination and development of areas in which they have a common interest. The members of the ad hoc committee were selected so as to represent a wide range of specialities which make use of animal tumour models in cancer research together with experts in animal husbandry and welfare and an observer from the
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