Excitotoxicity is a mechanism of neuronal injury, implicated in the pathogenesis of many
acute and chronic neurologic disorders, including perinatal brain injury associated with
hypoxia–ischemia and exposure to intrauterine inflammation. Glutamate, the primary
excitatory neurotransmitter, signals through N-methyl-d-aspartic acid (NMDA)/α-amino-3-
hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors. Proper functioning of both of
these receptors, in conjunction with glutamate signaling, is crucial for normal development …