Cytomegalovirus infection of trophoblast cells elicits an inflammatory response: a possible mechanism of placental dysfunction
D Chou, Y Ma, J Zhang, C McGrath, S Parry - American journal of obstetrics …, 2006 - Elsevier
OBJECTIVE: We sought to determine whether cytomegalovirus infection of extravillous
trophoblast cells induces inflammatory changes that lead to cell death. STUDY DESIGN:
Extravillous trophoblast (HTR-8/SVneo) cells were infected with cytomegalovirus. Cell death
assays were performed 8 to 48 hours after infection. The expression and secretion of
cytokines (interleukin-6 and-8) preceding cell death was measured by polymerase chain
reaction and enzyme-linked immunosorbent assay. RESULTS: Cell viability (lactate …
trophoblast cells induces inflammatory changes that lead to cell death. STUDY DESIGN:
Extravillous trophoblast (HTR-8/SVneo) cells were infected with cytomegalovirus. Cell death
assays were performed 8 to 48 hours after infection. The expression and secretion of
cytokines (interleukin-6 and-8) preceding cell death was measured by polymerase chain
reaction and enzyme-linked immunosorbent assay. RESULTS: Cell viability (lactate …