CMV infection, TLR‐2 and‐4 expression, and cytokine profiles in early‐onset preeclampsia with HELLP syndrome
F Xie, P von Dadelszen… - American Journal of …, 2014 - Wiley Online Library
F Xie, P von Dadelszen, J Nadeau
American Journal of Reproductive Immunology, 2014•Wiley Online LibraryProblem Cytomegalovirus (CMV) infection was previously reported in pregnancy
complications. However, its seroprevalence and associated Toll‐like receptor (TLR)
expression in early‐onset preeclampsia (EOPE) with hemolysis, elevated liver enzyme and
low platelets syndrome (HELLP s) are unexplored. Method of study A case–control study
was performed to examine maternal CMV antibodies, neutrophil Toll‐like receptor (TLR)‐2
and‐4 expression as well as the cytokine profile in EOPE with HELLP s (EOPE‐HELLP s)(n …
complications. However, its seroprevalence and associated Toll‐like receptor (TLR)
expression in early‐onset preeclampsia (EOPE) with hemolysis, elevated liver enzyme and
low platelets syndrome (HELLP s) are unexplored. Method of study A case–control study
was performed to examine maternal CMV antibodies, neutrophil Toll‐like receptor (TLR)‐2
and‐4 expression as well as the cytokine profile in EOPE with HELLP s (EOPE‐HELLP s)(n …
Problem
Cytomegalovirus (CMV) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll‐like receptor (TLR) expression in early‐onset preeclampsia (EOPE) with hemolysis, elevated liver enzyme and low platelets syndrome (HELLPs) are unexplored.
Method of study
A case–control study was performed to examine maternal CMV antibodies, neutrophil Toll‐like receptor (TLR)‐2 and ‐4 expression as well as the cytokine profile in EOPE with HELLPs (EOPE‐HELLPs) (n = 10), late‐onset preeclampsia (LOPE) (n = 20), normal pregnancy (n = 60), and non‐pregnancy (n = 20) controls.
Results
EOPE‐HELLPs had significantly increased CMV IgG sero‐positivity, upregulated TLR‐2/‐4 mRNA expression, increased serum IL‐6 and TNF‐α, and reduced IL‐10 compared with matched normal and non‐pregnancy controls. No significant difference was observed between LOPE and normal pregnancy controls.
Conclusion
We observed a significant association between CMV IgG sero‐positivity and innate immune response in EOPE‐HELLPs. Our data suggest that CMV infection may be a risk factor for this disorder.
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