[HTML][HTML] Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid

J Di Domizio, R Zhang, LJ Stagg, M Gagea… - Journal of Biological …, 2012 - ASBMB
Ample evidence suggests that almost all polypeptides can either adopt a native structure
(folded or intrinsically disordered) or form misfolded amyloid fibrils. Soluble protein
oligomers exist as an intermediate between these two states, and their cytotoxicity has been
implicated in the pathology of multiple human diseases. However, the mechanism by which
soluble protein oligomers develop into insoluble amyloid fibrils is not clear, and investigation
of this important issue is hindered by the unavailability of stable protein oligomers. Here, we …