[HTML][HTML] Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation
BM Hybertson, B Gao, SK Bose, JM McCord - Molecular aspects of …, 2011 - Elsevier
For the past 40years or so, oxidative stress has been increasingly recognized as a
contributing factor in aging and in various forms of pathophysiology generally associated
with aging. Our view of oxidative stress has been largely “superoxide-centric”, as we focused
on the pathological sources of this oxygen-derived free radical and the types of molecular
havoc it can wreak, as well as on the protection provided by the antioxidant enzymes,
especially the superoxide dismutases, catalases, and glutathione peroxidases. In the last …
contributing factor in aging and in various forms of pathophysiology generally associated
with aging. Our view of oxidative stress has been largely “superoxide-centric”, as we focused
on the pathological sources of this oxygen-derived free radical and the types of molecular
havoc it can wreak, as well as on the protection provided by the antioxidant enzymes,
especially the superoxide dismutases, catalases, and glutathione peroxidases. In the last …