[HTML][HTML] Infliximab and etanercept are equally effective in reducing enterocyte APOPTOSIS in experimental colitis

W Fries, C Muja, C Crisafulli, G Costantino… - … Journal of Medical …, 2008 - ncbi.nlm.nih.gov
W Fries, C Muja, C Crisafulli, G Costantino, G Longo, S Cuzzocrea, E Mazzon
International Journal of Medical Sciences, 2008ncbi.nlm.nih.gov
Loss of epithelial barrier integrity is considered an early step in the pathogenesis of Crohn's
disease (CD), and the rate of enterocyte apoptosis is one of the determinants of the intestinal
barrier function. Tumor necrosis factor-α (TNF-α), one of the major proinflammatory
mediators in CD, is one of the extrinsic signals which initiate apoptosis of enterocytes. The
aim of this study was to investigate the early effects of experimental colitis on enterocyte
apoptosis, and the effects of two anti-TNF treatments, infliximab (IFX) and etanercept (ETC) …
Abstract
Loss of epithelial barrier integrity is considered an early step in the pathogenesis of Crohn's disease (CD), and the rate of enterocyte apoptosis is one of the determinants of the intestinal barrier function. Tumor necrosis factor-α (TNF-α), one of the major proinflammatory mediators in CD, is one of the extrinsic signals which initiate apoptosis of enterocytes. The aim of this study was to investigate the early effects of experimental colitis on enterocyte apoptosis, and the effects of two anti-TNF treatments, infliximab (IFX) and etanercept (ETC). In addition, the importance of receptor I for TNF was tested in TNFR-1-/-mice.
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