[HTML][HTML] NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2

Y Yang, C Yin, A Pandey, D Abbott, C Sassetti… - Journal of Biological …, 2007 - ASBMB
The Rip2 kinase contains a caspase recruitment domain and has been implicated in the
activation of the transcriptional factor NF-κB downstream of Toll-like receptors, Nod-like
receptors, and the T cell receptor. Although Rip2 has been linked to Nod signaling, how Nod-
Rip2 proteins mediate NF-κB activation has remained unclear. We find Rip2 required for
Nod2-mediated NF-κB activation and to a lesser extent mitogen-activated protein kinase
activation. We demonstrate that Rip2 and IκB kinase-γ become stably polyubiquitinated …