[HTML][HTML] Novel regulation of CD80/CD86-induced phosphatidylinositol 3-kinase signaling by NOTCH1 protein in interleukin-6 and indoleamine 2, 3-dioxygenase …

C Koorella, JR Nair, ME Murray, LM Carlson… - Journal of Biological …, 2014 - ASBMB
Dendritic cells (DC) play a critical role in modulating antigen-specific immune responses
elicited by T cells via engagement of the prototypic T cell costimulatory receptor CD28 by the
cognate ligands CD80/CD86, expressed on DC. Although CD28 signaling in T cell
activation has been well characterized, it has only recently been shown that CD80/CD86,
which have no demonstrated binding domains for signaling proteins in their cytoplasmic
tails, nonetheless also transduce signals to the DC. Functionally, CD80/CD86 engagement …