The return of the nucleus: transcriptional and epigenetic control of autophagy

J Füllgrabe, DJ Klionsky, B Joseph - Nature reviews Molecular cell …, 2014 - nature.com
Nature reviews Molecular cell biology, 2014nature.com
Autophagy is a conserved process by which cytoplasmic components are degraded by the
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were
not considered of primary importance for this process. However, recent studies have
unveiled a transcriptional and epigenetic network that regulates autophagy. The
identification of tightly controlled transcription factors (such as TFEB and ZKSCAN3),
microRNAs and histone marks (especially acetylated Lys16 of histone 4 (H4K16ac) and …
Abstract
Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigenetic network that regulates autophagy. The identification of tightly controlled transcription factors (such as TFEB and ZKSCAN3), microRNAs and histone marks (especially acetylated Lys16 of histone 4 (H4K16ac) and dimethylated H3K9 (H3K9me2)) associated with the autophagic process offers an attractive conceptual framework to understand the short-term transcriptional response and potential long-term responses to autophagy.
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