Critical roles of non-histone protein lysine methylation in human tumorigenesis

R Hamamoto, V Saloura, Y Nakamura - Nature Reviews Cancer, 2015 - nature.com
Nature Reviews Cancer, 2015nature.com
Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their
dysregulation is involved in the development and progression of various diseases, including
cancer, and these enzymes are now considered to be potential therapeutic targets. Although
most studies have focused on histone methylation, many reports have revealed that these
enzymes also regulate the methylation dynamics of non-histone proteins such as p53, RB1 …
Abstract
Several protein lysine methyltransferases and demethylases have been identified to have critical roles in histone modification. A large body of evidence has indicated that their dysregulation is involved in the development and progression of various diseases, including cancer, and these enzymes are now considered to be potential therapeutic targets. Although most studies have focused on histone methylation, many reports have revealed that these enzymes also regulate the methylation dynamics of non-histone proteins such as p53, RB1 and STAT3 (signal transducer and activator of transcription 3), which have important roles in human tumorigenesis. In this Review, we summarize the molecular functions of protein lysine methylation and its involvement in human cancer, with a particular focus on lysine methylation of non-histone proteins.
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