N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation

L Verna, J Whysner, GM Williams - Pharmacology & therapeutics, 1996 - Elsevier
L Verna, J Whysner, GM Williams
Pharmacology & therapeutics, 1996Elsevier
N-Nitrosodiethylamine (NDEA) is DNA reactive after bioactivation and produces tumors in
every animal species tested. Bioactivation is effected by several P450 isozymes including
CYP2E1, which is ethanol inducible. Tumor formation in rat liver was proportional to O4-
ethyldeoxythymidine formation in DNA, which was generally proportional to NDEA dose. At
low doses in the 0.033–1.1 ppm range, the doseresponse for esophageal tumor formation
was sublinear, possibly due to DNA repair. Although no epidemiological studies have …
N-Nitrosodiethylamine (NDEA) is DNA reactive after bioactivation and produces tumors in every animal species tested. Bioactivation is effected by several P450 isozymes including CYP2E1, which is ethanol inducible. Tumor formation in rat liver was proportional to O4-ethyldeoxythymidine formation in DNA, which was generally proportional to NDEA dose. At low doses in the 0.033–1.1 ppm range, the doseresponse for esophageal tumor formation was sublinear, possibly due to DNA repair. Although no epidemiological studies have specifically evaluated NDEA, sufficient exposure levels would be expected to cause cancer in humans.
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