[HTML][HTML] A marker for Stevens–Johnson syndrome

WH Chung, SI Hung, HS Hong, MS Hsih, LC Yang… - Nature, 2004 - nature.com
WH Chung, SI Hung, HS Hong, MS Hsih, LC Yang, HC Ho, JY Wu, YT Chen
Nature, 2004nature.com
Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-
threatening reactions of the skin to particular types of medication,,. Here we show that there
is a strong association in Han Chinese between a genetic marker, the human leukocyte
antigen HLA–B* 1502, and Stevens–Johnson syndrome induced by carbamazepine, a drug
commonly prescribed for the treatment of seizures. It should be possible to exploit this
association in a highly reliable test to predict severe adverse reaction, as well as for …
Abstract
Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication,,. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA–B*1502, and Stevens–Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens–Johnson syndrome.
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