[HTML][HTML] CO2/HCO3−-and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor
JH Zippin, Y Chen, SG Straub, KC Hess, A Diaz… - Journal of Biological …, 2013 - ASBMB
The second messenger molecule cAMP is integral for many physiological processes. In
mammalian cells, cAMP can be generated from hormone-and G protein-regulated
transmembrane adenylyl cyclases or via the widely expressed and structurally and
biochemically distinct enzyme soluble adenylyl cyclase (sAC). sAC activity is uniquely
stimulated by bicarbonate ions, and in cells, sAC functions as a physiological carbon
dioxide, bicarbonate, and pH sensor. sAC activity is also stimulated by calcium, and its …
mammalian cells, cAMP can be generated from hormone-and G protein-regulated
transmembrane adenylyl cyclases or via the widely expressed and structurally and
biochemically distinct enzyme soluble adenylyl cyclase (sAC). sAC activity is uniquely
stimulated by bicarbonate ions, and in cells, sAC functions as a physiological carbon
dioxide, bicarbonate, and pH sensor. sAC activity is also stimulated by calcium, and its …
