Uncoupling protein 1 and sarcolipin are required to maintain optimal thermogenesis, and loss of both systems compromises survival of mice under cold stress
LA Rowland, NC Bal, LP Kozak, M Periasamy - Journal of Biological …, 2015 - ASBMB
The importance of brown adipose tissue as a site of nonshivering thermogenesis has been
well documented. Emerging studies suggest that skeletal muscle is also an important site of
thermogenesis especially when brown adipose tissue function is lacking. We recently
showed that sarcolipin (SLN), an uncoupler of the sarco (endo) plasmic reticulum Ca 2+
ATPase (SERCA) pump, could contribute to heat production in skeletal muscle. In this study,
we sought to understand how loss of UCP1 or SLN is compensated during cold exposure …
well documented. Emerging studies suggest that skeletal muscle is also an important site of
thermogenesis especially when brown adipose tissue function is lacking. We recently
showed that sarcolipin (SLN), an uncoupler of the sarco (endo) plasmic reticulum Ca 2+
ATPase (SERCA) pump, could contribute to heat production in skeletal muscle. In this study,
we sought to understand how loss of UCP1 or SLN is compensated during cold exposure …
