Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome: a new approach: proof of principle
WJ Kox, RC Bone, D Krausch, WD Döcke… - Archives of internal …, 1997 - jamanetwork.com
Background: Immunoparalysis is defined as a decrease in the level of HLA-DR expression
on monocytes during the course of sepsis. Objective: To evaluate whether interferon gamma-
1b has an immunoregulatory effect in patients with immunoparalysis during the
compensatory anti-inflammatory response syndrome. Methods: Of the patients admitted
consecutively to the intensive care unit for the management of sepsis, 10 received interferon
gamma-1b, 100 μg per 0.5 mL, after confirmation of HLA-DR expression of less than 30% on …
on monocytes during the course of sepsis. Objective: To evaluate whether interferon gamma-
1b has an immunoregulatory effect in patients with immunoparalysis during the
compensatory anti-inflammatory response syndrome. Methods: Of the patients admitted
consecutively to the intensive care unit for the management of sepsis, 10 received interferon
gamma-1b, 100 μg per 0.5 mL, after confirmation of HLA-DR expression of less than 30% on …
