11β-Hydroxysteroid dehydrogenase type 1 in obese subjects with type 2 diabetes mellitus
X Li, J Wang, Q Yang, S Shao - The American Journal of the Medical …, 2017 - Elsevier
Obesity is one of the most significant contributors to the development of type 2 diabetes
mellitus. Tissue-specific glucocorticoids regulated by 11β-hydroxysteroid dehydrogenase
enzyme (11β-HSD) type 1 are involved in central obesity and obesity-related comorbidities.
Moderate downregulation of 11β-HSD1 can attenuate insulin insensitivity and the
impairment of glucose-stimulated insulin secretion. Some of the beneficial effects of 11β-
HSD1 inhibition may be mediated, at least in part, through inactivation of tissue-specific …
mellitus. Tissue-specific glucocorticoids regulated by 11β-hydroxysteroid dehydrogenase
enzyme (11β-HSD) type 1 are involved in central obesity and obesity-related comorbidities.
Moderate downregulation of 11β-HSD1 can attenuate insulin insensitivity and the
impairment of glucose-stimulated insulin secretion. Some of the beneficial effects of 11β-
HSD1 inhibition may be mediated, at least in part, through inactivation of tissue-specific …
