IgG subclasses determine pathways of anaphylaxis in mice
H Beutier, CM Gillis, B Iannascoli, O Godon… - Journal of Allergy and …, 2017 - Elsevier
Background Animal models have demonstrated that allergen-specific IgG confers sensitivity
to systemic anaphylaxis that relies on IgG Fc receptors (FcγRs). Mouse IgG 2a and IgG 2b
bind activating FcγRI, FcγRIII, and FcγRIV and inhibitory FcγRIIB; mouse IgG 1 binds only
FcγRIII and FcγRIIB. Although these interactions are of strikingly different affinities, these 3
IgG subclasses have been shown to enable induction of systemic anaphylaxis. Objective We
sought to determine which pathways control the induction of IgG 1-, IgG 2a-, and IgG 2b …
to systemic anaphylaxis that relies on IgG Fc receptors (FcγRs). Mouse IgG 2a and IgG 2b
bind activating FcγRI, FcγRIII, and FcγRIV and inhibitory FcγRIIB; mouse IgG 1 binds only
FcγRIII and FcγRIIB. Although these interactions are of strikingly different affinities, these 3
IgG subclasses have been shown to enable induction of systemic anaphylaxis. Objective We
sought to determine which pathways control the induction of IgG 1-, IgG 2a-, and IgG 2b …
