Gene expression markers of age-related inflammation in two human cohorts
Introduction Chronically elevated circulating inflammatory markers are common in older
persons but mechanisms are unclear. Many blood transcripts (> 800 genes) are associated
with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene
transcripts statistically mediating, as drivers or responders, the increasing levels of IL6
protein in blood at older ages. Methods Blood derived in-vivo RNA from the Framingham
Heart Study (FHS, n= 2422, ages 40–92 yrs) and InCHIANTI study (n= 694, ages 30–104 …
persons but mechanisms are unclear. Many blood transcripts (> 800 genes) are associated
with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene
transcripts statistically mediating, as drivers or responders, the increasing levels of IL6
protein in blood at older ages. Methods Blood derived in-vivo RNA from the Framingham
Heart Study (FHS, n= 2422, ages 40–92 yrs) and InCHIANTI study (n= 694, ages 30–104 …
