Assessment of the validity of nuclear-localized androgen receptor splice variant 7 in circulating tumor cells as a predictive biomarker for castration-resistant prostate …
Importance A blood test to determine whether to treat patients with metastatic castration-
resistant prostate cancer (mCRPC) with an androgen receptor signaling (ARS) inhibitor or
taxane is an unmet medical need. Objective To determine whether a validated assay for the
nuclear-localized androgen receptor splice variant 7 (AR-V7) protein in circulating tumor
cells can determine differential overall survival among patients with mCRPC treated with
taxanes vs ARS inhibitors. Design, Setting, and Participants This blinded correlative study …
resistant prostate cancer (mCRPC) with an androgen receptor signaling (ARS) inhibitor or
taxane is an unmet medical need. Objective To determine whether a validated assay for the
nuclear-localized androgen receptor splice variant 7 (AR-V7) protein in circulating tumor
cells can determine differential overall survival among patients with mCRPC treated with
taxanes vs ARS inhibitors. Design, Setting, and Participants This blinded correlative study …
