Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
Introduction TREM2 is involved in the regulation of inflammatory response and
phagocytosis. A soluble fragment (sTREM2) is often found abnormally increased in
cerebrospinal fluid (CSF) in Alzheimer's disease (AD). Methods One hundred fourteen
participants (45 control, 19 preclinical, 27 mild cognitive impairment [MCI], and 23 AD)
underwent CSF sTREM2 determination and magnetic resonance imaging (MRI). We studied
the association between CSF sTREM2, gray matter volume, and water motion diffusivity and …
phagocytosis. A soluble fragment (sTREM2) is often found abnormally increased in
cerebrospinal fluid (CSF) in Alzheimer's disease (AD). Methods One hundred fourteen
participants (45 control, 19 preclinical, 27 mild cognitive impairment [MCI], and 23 AD)
underwent CSF sTREM2 determination and magnetic resonance imaging (MRI). We studied
the association between CSF sTREM2, gray matter volume, and water motion diffusivity and …
