Indoleamine 2, 3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge
A Salazar, BL Gonzalez-Rivera, L Redus… - Hormones and …, 2012 - Elsevier
This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.”
Upregulation of indoleamine 2, 3-dioxygenase (IDO) by proinflammatory cytokines has been
implicated as a biological mediator of inflammation-related mood disorders. Clinical reports
on this neuro-immune interaction remain correlative, while mechanism-centered preclinical
experiments have focused on a relatively narrow, and somewhat controversial, survey of
depression-like behaviors that include the forced swim and tail suspension tests. Here, we …
Upregulation of indoleamine 2, 3-dioxygenase (IDO) by proinflammatory cytokines has been
implicated as a biological mediator of inflammation-related mood disorders. Clinical reports
on this neuro-immune interaction remain correlative, while mechanism-centered preclinical
experiments have focused on a relatively narrow, and somewhat controversial, survey of
depression-like behaviors that include the forced swim and tail suspension tests. Here, we …
