Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx
R Schindl, R Fritsch, I Jardin, I Frischauf, H Kahr… - Journal of Biological …, 2012 - ASBMB
TRP proteins mostly assemble to homomeric channels but can also heteromerize,
preferentially within their subfamilies. The TRPC1 protein is the most versatile member and
forms various TRPC channel combinations but also unique channels with the distantly
related TRPP2 and TRPV4. We show here a novel cross-family interaction between TRPC1
and TRPV6, a Ca 2+ selective member of the vanilloid TRP subfamily. TRPV6 exhibited
substantial co-localization and in vivo interaction with TRPC1 in HEK293 cells, however, no …
preferentially within their subfamilies. The TRPC1 protein is the most versatile member and
forms various TRPC channel combinations but also unique channels with the distantly
related TRPP2 and TRPV4. We show here a novel cross-family interaction between TRPC1
and TRPV6, a Ca 2+ selective member of the vanilloid TRP subfamily. TRPV6 exhibited
substantial co-localization and in vivo interaction with TRPC1 in HEK293 cells, however, no …
