Broadly neutralizing antibodies and the development of vaccines
BF Haynes, T Bradley - Jama, 2015 - jamanetwork.com
Human immunodeficiency virus (HIV) infects 2.5 million people worldwide and accounts for
more than 1 million deaths every year. Thus, an HIV vaccine is desperately needed. One
roadblock to development of an effective HIV vaccine is the extraordinary ability of HIV to
mutate and evolve into myriad quasi-species. Therefore, a key goal in developing a
successful HIV vaccine is the induction of antibodies that can recognize and neutralize the
majority of HIV quasi-species, called broadly reactive neutralizing antibodies (bnAbs). The …
more than 1 million deaths every year. Thus, an HIV vaccine is desperately needed. One
roadblock to development of an effective HIV vaccine is the extraordinary ability of HIV to
mutate and evolve into myriad quasi-species. Therefore, a key goal in developing a
successful HIV vaccine is the induction of antibodies that can recognize and neutralize the
majority of HIV quasi-species, called broadly reactive neutralizing antibodies (bnAbs). The …