[HTML][HTML] Persistent HIV-1 viremia on antiretroviral therapy: measurement and mechanisms
JL Jacobs, EK Halvas, MA Tosiano… - Frontiers in …, 2019 - frontiersin.org
JL Jacobs, EK Halvas, MA Tosiano, JW Mellors
Frontiers in microbiology, 2019•frontiersin.orgHIV-1 viremia persists at low-levels despite clinically effective antiretroviral therapy (ART).
Here we review new methods to quantify and characterize persistent viremia at the single
genome level, and discuss the mechanisms of persistence including clonal expansion of
infected cells and tissue origins of viremia. A deeper understanding of how viremia persists
on ART is critically important to the design of therapies to eliminate viremia and achieve a
functional cure for HIV-1.
Here we review new methods to quantify and characterize persistent viremia at the single
genome level, and discuss the mechanisms of persistence including clonal expansion of
infected cells and tissue origins of viremia. A deeper understanding of how viremia persists
on ART is critically important to the design of therapies to eliminate viremia and achieve a
functional cure for HIV-1.
HIV-1 viremia persists at low-levels despite clinically effective antiretroviral therapy (ART). Here we review new methods to quantify and characterize persistent viremia at the single genome level, and discuss the mechanisms of persistence including clonal expansion of infected cells and tissue origins of viremia. A deeper understanding of how viremia persists on ART is critically important to the design of therapies to eliminate viremia and achieve a functional cure for HIV-1.
Frontiers