We previously have shown that experimental fractures exposed to ciprofloxacin have
diminished fracture healing. The purpose of this study was to assess the effect of
levofloxacin and trovafloxacin on experimental fracture healing to test the hypothesis that
diminished fracture healing is a quinolone class effect. Sixty-one male Wistar rats were
divided into three groups, which received 25 mg/kg of levofloxacin twice daily for 3 weeks,
35 mg/kg of trovafloxacin twice daily for 3 weeks, or no treatment, beginning 7 days after …

Background: Fluoroquinolones, such as ciprofloxacin, have an adverse effect on growing
cartilage and endochondral ossification in children. This study was carried out to determine
whether ciprofloxacin also has an adverse effect on the healing of experimental fractures.
Methods: Sixty male 300-gram Wistar rats were divided equally into three groups, which
received ciprofloxacin, cefazolin, or no treatment for three weeks, beginning seven days
after production of a closed, non-displaced, bilateral femoral fracture. The serum …