Early skeletal and biochemical alterations in pediatric chronic kidney disease
K Wesseling-Perry, RC Pereira, CH Tseng… - Clinical Journal of the …, 2012 - journals.lww.com
Results Serum phosphorus levels were increased in 4% of patients with stage 3 CKD and
43% of those with stage 4/5 CKD. Parathyroid hormone concentrations were elevated in
36% of patients with stage 2, 71% with stage 3, and 93% with stage 4/5 CKD, whereas FGF-
23 values were elevated in 81% of all patients, regardless of CKD stage. Bone turnover was
normal in all patients with stage 2, but was increased in 13% with stage 3 and 29% with
stage 4/5 CKD. Defective mineralization was present in 29% of patients with stage 2, 42 …
43% of those with stage 4/5 CKD. Parathyroid hormone concentrations were elevated in
36% of patients with stage 2, 71% with stage 3, and 93% with stage 4/5 CKD, whereas FGF-
23 values were elevated in 81% of all patients, regardless of CKD stage. Bone turnover was
normal in all patients with stage 2, but was increased in 13% with stage 3 and 29% with
stage 4/5 CKD. Defective mineralization was present in 29% of patients with stage 2, 42 …