[HTML][HTML] FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization
OJ Park, HJ Kim, KM Woo, JH Baek… - Journal of biological …, 2010 - ASBMB
Runx2 is a key transcription factor regulating osteoblast differentiation and skeletal
morphogenesis, and FGF2 is one of the most important regulators of skeletal development.
The importance of the ERK mitogen-activated protein (MAP) kinase pathway in cranial
suture development was demonstrated by the findings that the inhibition of FGF/FGF
receptor (FGFR) signaling by a MEK blocker prevents the premature suture closure caused
by an Fgfr2 mutation in mice. We previously demonstrated that ERK activation does not …
morphogenesis, and FGF2 is one of the most important regulators of skeletal development.
The importance of the ERK mitogen-activated protein (MAP) kinase pathway in cranial
suture development was demonstrated by the findings that the inhibition of FGF/FGF
receptor (FGFR) signaling by a MEK blocker prevents the premature suture closure caused
by an Fgfr2 mutation in mice. We previously demonstrated that ERK activation does not …