[HTML][HTML] mRNA expression signature of Gleason grade predicts lethal prostate cancer
KL Penney, JA Sinnott, K Fall, Y Pawitan… - Journal of Clinical …, 2011 - ncbi.nlm.nih.gov
Journal of Clinical Oncology, 2011•ncbi.nlm.nih.gov
Purpose Prostate-specific antigen screening has led to enormous overtreatment of prostate
cancer because of the inability to distinguish potentially lethal disease at diagnosis. We
reasoned that by identifying an mRNA signature of Gleason grade, the best predictor of
prognosis, we could improve prediction of lethal disease among men with moderate
Gleason 7 tumors, the most common grade, and the most indeterminate in terms of
prognosis.
cancer because of the inability to distinguish potentially lethal disease at diagnosis. We
reasoned that by identifying an mRNA signature of Gleason grade, the best predictor of
prognosis, we could improve prediction of lethal disease among men with moderate
Gleason 7 tumors, the most common grade, and the most indeterminate in terms of
prognosis.
Abstract
Purpose
Prostate-specific antigen screening has led to enormous overtreatment of prostate cancer because of the inability to distinguish potentially lethal disease at diagnosis. We reasoned that by identifying an mRNA signature of Gleason grade, the best predictor of prognosis, we could improve prediction of lethal disease among men with moderate Gleason 7 tumors, the most common grade, and the most indeterminate in terms of prognosis.
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