Genetics of adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common pediatric musculoskeletal disorder,
affecting about 2–3% of the children worldwide. The underlying etiology of AIS has proven
elusive, in part due to the lack of appropriate animal models and systems that would enable
laboratory-based research. In contrast, genetic studies in patient populations have
highlighted several candidate genes suggesting possible neuromuscular origins.
Developing genetically defined animal models to facilitate hypothesis testing is a high …
affecting about 2–3% of the children worldwide. The underlying etiology of AIS has proven
elusive, in part due to the lack of appropriate animal models and systems that would enable
laboratory-based research. In contrast, genetic studies in patient populations have
highlighted several candidate genes suggesting possible neuromuscular origins.
Developing genetically defined animal models to facilitate hypothesis testing is a high …