A detailed protocol for characterizing the murine C1498 cell line and its associated leukemia mouse model
A Mopin, V Driss, C Brinster - JoVE (Journal of Visualized Experiments), 2016 - jove.com
The intravenous injection of C1498 cells into syngeneic or congenic mice has been
performed since 1941. These injections result in the development of acute leukemia.
However, the nature of this disease has not been well documented in the literature. Here, we
provide a technical protocol for characterizing C1498 cells in vitro and for determining the
nature of the induced leukemia in vivo. The first part of this procedure is focused on
determining the hematopoietic lineage and the stage of differentiation of cultured C1498 …
performed since 1941. These injections result in the development of acute leukemia.
However, the nature of this disease has not been well documented in the literature. Here, we
provide a technical protocol for characterizing C1498 cells in vitro and for determining the
nature of the induced leukemia in vivo. The first part of this procedure is focused on
determining the hematopoietic lineage and the stage of differentiation of cultured C1498 …