Mutagenesis of the runt domain defines two energetic hot spots for heterodimerization with the core binding factor β subunit
L Zhang, Z Li, J Yan, P Pradhan, T Corpora… - Journal of Biological …, 2003 - ASBMB
Core-binding factors (CBFs) are a small family of heterodimeric transcription factors that play
critical roles in several developmental pathways and in human disease. Mutations in CBF
genes are found in leukemias, bone disorders, and gastric cancers. CBFs consist of a DNA-
binding CBFα subunit (Runx1, Runx2, or Runx3) and a non-DNA-binding CBFβ subunit.
CBFα binds DNA in a sequence-specific manner, whereas CBFβ enhances DNA binding by
CBFα. Both DNA binding and heterodimerization with CBFβ are mediated by a single …
critical roles in several developmental pathways and in human disease. Mutations in CBF
genes are found in leukemias, bone disorders, and gastric cancers. CBFs consist of a DNA-
binding CBFα subunit (Runx1, Runx2, or Runx3) and a non-DNA-binding CBFβ subunit.
CBFα binds DNA in a sequence-specific manner, whereas CBFβ enhances DNA binding by
CBFα. Both DNA binding and heterodimerization with CBFβ are mediated by a single …
