[HTML][HTML] Roles for c-Myc in self-renewal of hematopoietic stem cells
Y Satoh, I Matsumura, H Tanaka, S Ezoe… - Journal of Biological …, 2004 - ASBMB
Notch and HOXB4 have been reported to expand hematopoietic stem cells (HSCs) in vitro.
However, their critical effector molecules remain undetermined. We found that the
expression of c-myc, cyclin D2, cyclin D3, cyclin E, and E2F1 was induced or enhanced
during Notch1-or HOXB4-induced self-renewal of murine HSCs. Since c-Myc can act as a
primary regulator of G 1/S transition, we examined whether c-Myc alone can induce self-
renewal of HSCs. In culture with stem cell factor, FLT3 ligand, and IL-6, a 4 …
However, their critical effector molecules remain undetermined. We found that the
expression of c-myc, cyclin D2, cyclin D3, cyclin E, and E2F1 was induced or enhanced
during Notch1-or HOXB4-induced self-renewal of murine HSCs. Since c-Myc can act as a
primary regulator of G 1/S transition, we examined whether c-Myc alone can induce self-
renewal of HSCs. In culture with stem cell factor, FLT3 ligand, and IL-6, a 4 …