PI3K–AKT pathway mediates growth and survival signals during development of fetal mouse lung
J Wang, T Ito, N Udaka, K Okudela, T Yazawa… - Tissue and Cell, 2005 - Elsevier
We examined the roles of the PI3K–AKT signalling pathway in fetal lung development. By
Western blotting, phosphorylated AKT (pAKT) was highly expressed in fetal days 12 and 14
with decreased expression thereafter. By immunohistochemistry, pAKT was expressed
mainly in the respiratory epithelium of early fetal days. We examined the effects of fibroblast
growth factor 1 (FGF1), PI3K inhibitors (LY294002 and wortmannin), MAPK inhibitor
(PD98059) and both of FGF1 and each inhibitor on lung morphogenesis, BrdU incorporation …
Western blotting, phosphorylated AKT (pAKT) was highly expressed in fetal days 12 and 14
with decreased expression thereafter. By immunohistochemistry, pAKT was expressed
mainly in the respiratory epithelium of early fetal days. We examined the effects of fibroblast
growth factor 1 (FGF1), PI3K inhibitors (LY294002 and wortmannin), MAPK inhibitor
(PD98059) and both of FGF1 and each inhibitor on lung morphogenesis, BrdU incorporation …